Allostery Questions

1995

"To what extent does the allosteric mechanism of haemoglobin, as deduced
from structural data, conform to the classical two-state concerted
Monod-Wyman-Changeux model?  To what extent is this model generally
applicable to allosteric enzymes?"

1996

" 'Subunit interfaces provide the key to allosteric interactions.'
Discuss using specific examples."

1997

No questions.

1998

"With reference to three of the following, describe what is known of the
structural basis for:
(a)	Control of oxygen binding to haemoglobin by H+, CO2, and
	bisphosphoglycerate.
(b)	The catalytic mechanism of glycogen phosphorylase.
(c)	Substrate binding and regulation of phosphofructokinase.
(d)	The role of quaternary structure and subunit interactions in control
	of aspartate transcarbamoylase.
(e)	The allosteric regulation of the lac repressor."

1999

"Two models, the concerted and the sequential, which attempt to explain
the behaviour of allosteric proteins, were devised in the 1960s.  Describe
these two models, and discuss the extent to which they have been
substantiated by structural studies of allosteric proteins."

2000

No questions.