Drug Design References

• Hilary term, third year: Dr Noble's Structural Based Drug Design lectures.

• Gane and Dean, "Recent advances in structure-based rational drug design"; Current Opinion In Structural Biology 10 (4), 401-404 (2000).

• Mao et al, "Structure-based drug design of non-nucleoside inhibitors for wild-type and drug-resistant HIV reverse transcriptase"; Biochemical Pharmacology 60 (9), 1251-1265 (2000).

• Bartolucci et al, "Three-dimensional structure of a complex of galanthamine (Nivalin (R)) with acetylcholinesterase from Torpedo californica: Implications for the design of new anti-alzheimer drugs"; Proteins - Structure, Function, And Genetics 42 (2) 182-191 (2001).

• Aronov et al, "Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design"; Journal Of Medicinal Chemistry 41 (24), 4790-4799 (1998).

• Kempf et al, "Discovery of Ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficiency"; Journal Of Medicinal Chemistry 41 (4), 602-617 (1998).

This page was written by Niall Harrison.