Protein-Nucleic Acid Interaction Questions

1995

"Either:

(a) Describe, with examples, major classes of protein fold found in
water-soluble proteins.  Discuss why these folds may frequently be found
organised in domains.

Or:

(b) Give and account of three distinct modes by which proteins bind to
their target sites on DNA."

1996

"The partial structure of three types of DNA-protein complex are shown in
Figures 1a, b, c.  Describe salient features of the complexes that relate
to the binding of the proteins to specific sequences in the DNA.  Where
appropriate, draw on the diagrams to show points being made.  Give an
example of each type of complex.  For each example, indicate how the
protein-DNA interaction relates to biological function."

(Check to see what the pictures are of…)

1997

"Illustrate how differences between DNA and RNA structure are reflected in
the ways proteins interact with them."

1998

" 'Conformational changes in the structure of duplex DNA occur in many of
its interactions with proteins and are important for recognition and
biological function.'  Discuss."

1999

No questions.

2000

"How have structural studies contributed to our understanding of specific
and non-specific protein-DNA interactions?"