| Index | I | II | III | IV | VI |
Michelmas term/Hilary term, second year: Prof Campbell's Physical Methods lectures.
Michelmas term, third year: Prof Campbell's NMR Of Macromolecules lectures.
Michelmas term, third year: Prof Noble's Macromolecular Crystallography lectures (although there doesn't seem to be an entry in the departmental web handbook for these).
Michelmas term, third year: The Spectroscopy data-handling.
Michelmas term, third year: The Crystallography data-handling.
This space left blank...if you know of anything I can fill it with, please tell me!
A webpage giving an introduction to FTIR.
Jager, S et al, "Chromophore structural changes in rhodopsin from nanoseconds to microseconds following pigment photolysis"; PNAS 94(16), 8557-8562 (1997).
A thread on ox.bioch.misc about IR spectroscopy; Tom Anderson's summary is here.
A very simple introduction to fluorescence, with key terms clearly explained.
Millar, D, "Time-Resolved Fluorescence Spectroscopy"; Current Opinion In Structural Biology 6(5), 637-642 (1996).
Tsien, R, "The Green Fluorescent Protein"; Annual Review Of Biochemistry 67, 509-544 (1998).
Bet you didn't know that Scorpions fluoresced, did you? No. Well, now you do - amaze your friends!
A webpage about Circular Dichroism (CD).
Get the one-page lowdown on what small-angle X-ray scattering (SAXS) does here.
Trewhella, Jill, "Insights into biomolecular function from small-angle scattering"; Current Opinion In Structural Biology 7(5), 702-708 (1997).
A tutorial on small-angle X-ray scattering can be found here.
Kochendoerfer et al, "How colour visual pigments are tuned"; TIBS 24(8), 300-305 (1999). This is a Raman Spectroscopy reference.
For those who just can't get enough of that Raman magic, there's a links site here.
The University Of York molecular motors groups show you what you can do with some optical tweezers here.
Helmer, M, "Biophysics: Singular take on molecules"; Nature 401, 225-226 (1999). A News and Views article that covers the use of optical tweezers in DNA unwinding experiments.
Stowell, M et al, "Macromolecular structure determination by electron microscopy: New advances and recent results"; Current Opinion In Structural Biology, 8(5), 595-600 (1998).
Engel, A et al, "A forceful way with single molecules"; Current Biology 9(4), R133-R136 (1999). An atomic force microscopy (AFM) reference.
Politz, J, "Use of caged fluorochromes to track macromolecular movement in living cells"; Trends in Current Biology 9(7), 284-287 (1999). A fluorescence micropcopy reference.
If you've ever wondered how does a confocal microscope work...?, then this is the site for you.
Some examples of what you might see with a confocal microscope can be found here.
Where to start? Ah, with Martin's Distinctly Succint Guide to X-Ray Crystallography, of course!
There is a slightly more detailed guide here.
A completely complete guide to all things crystallographic can be found here.
A guide to those mystic Fourier Transforms might be helpful.
Grimes, J et al, "The atomic structure of the bluetongue virus core"; Nature 395, 470-478 (1998). Solved to 3.5 angstroms using X-ray crystallography.
Garrett, R, "Mechanics of the ribosome"; Nature 400, 811-812 (1999). A News and Views article describing the X-ray diffraction-obtained 5 angstrom structure of the ribosome.
A nice NMR tutorial can be found here.
...whereas this site will tell you just about everything you ever need to know about NMR. Yeah, it uses frames, but nothing's perfect...
A slightly less detailed guide. The 'structure determination' section is nice.
This site is a site of links to other NMR resources.
The homepage of a functional MRI lab.
Magnetic resonance microscopy - with some nice pictures.
The homepage of the Yale NMR research group.
A guide to structure determination of proteins with NMR spectroscopy - thanks to Heather Stoddart for this one.
Know of any good examples that are on-line? Tell me!
An overview of ESR and its applications can be found here.
Altenbach, et al, "Structural features and light-dependent changes in the cytoplasmic interhelical E-F loop region of rhodopsin: A site-directed spin-labelling study"; Biochemistry 35(38), 12470-12478 (1996).
Wu, J et al, "Site-directed spin labelling and chemical crosslinking demonstrate that helix V is close to helicse VII and VIII in the lactose permease of Escherichia coli"; PNAS 93(19), 10123-10127 (1996).
Everything you (n)ever wanted to know about SPR. Actually, this page is mainly useful as a source of SPR references; if I find something better, I'll link to that instead.
Could I interest you in an analytical ultracentrifugation solution interaction analysis system, sir?
I need more on centrifugation, viscosity measurements, electophoresis, and mass spectrometry to go here...let me know if you have any examples.
| Index | I | II | III | IV | VI |
This page was written by Niall Harrison.