Stimulus-Response Questions

1995

Either:

"Discuss how insulin can achieve an increase in the rate of glycogen
synthesis."

Or

"Compare and contrast cyclic AMP with inositol 1,4,5-triphosphate as
second messengers in controlling metabolism in eukaryotes."

1996

"The regulation of intracellular Ca2+ concentration involves movement of
Ca2+ ions across the plasma membrane, and both into and out of
intracellular Ca2+ stores.  How are these processes co-ordinated?"

"Assess critically the role of insulin receptor substrate 1 (IRS-1) in
insulin action."

1997

"Describe the role of the heterotrimeric guanine nucleotide-proteins (G
proteins) in coupling a hormone receptor complex to different enzymes and
in amplifying the stimulus."

1998

"Describe the signalling pathway by which insulin leads to the activation
of muscle glycogen synthase.  On what evidence is this pathway based?"

1999

"Discuss the importance of either inositol-containing compounds or Ca2+
ions in stimulus-response coupling."

2000

"Compare and contrast the regulation and roles of protein kinases A, B,
and C."

"Describe the roles of inositol-containing compounds in cellular
regulation."