DNA Replication Questions 1995 No questions. 1996 No questions. 1997 "What is DNA supercoiling and what is its biological relevance?" "Review the evidence supporting the current models for the initiation of DNA replication in eukaryotic cells." 1998 "Discuss the contribution of genetic studies in the elucidation of the mechanism of DNA replication." 1999 "Trace the progress of a DNA replication fork from replication initiation to termination in E.coli, indicating what proteins are required at different times, and what topological problems need to be overcome. Briefly outline any differences you would expect during the progress of a eukaryotic replication fork." 2000 "How can the initiation of DNA replication be detected in a eukaryotic cell? Describe the factors that may influence the timing of this initiation."