Death And Undeath Questions

N.B. These systems can also be used as examples in general signal
transduction questions.

1995

Paper IV:

"How has the study of tumour suppressor genes furthered our knowledge of
cell cycle control?"

Paper V:

"Write an essay on 'the relevance of mismatch repair to mutation,
recombination and cancer'."

1996

Paper IV:

No questions.

Paper V: 

'Write an essay on the molecular basis of cancer."

1997

Paper IV:

No questions.

Paper V:

"Discuss the influence of viral infection on the induction of tumours."

1998

Paper IV:

"Discuss the mechanisms whereby the subversion of normal growth factor
signalling leads to aberrant cell proliferation associated with the
malignant state."

"Give an account of intracellular events that influence the progression
and duration of the mitotic cell cycle.  Illustrate your answer with
reference to the events in normal and abnormal (e.g. virally infected or
tumour) cells."

Paper V:

"Contrast mitochondrial function in animals and plants."

1999

Paper IV:

"Compare and contrast the type of G-protein used in the physiological
signalling cascade leading to the breakdown of glycogen (in response to
glucagons or adrenaline) with the type of G-protein used in mitogenic
signalling cascades (in response to growth factors).  How may
externally-induced modification or the malfunctioning of these G-proteins
lead to disease?"

"Describe the mechanisms used to achieve apoptosis.  How do extracellular
signals influence the choice between cell division and apoptosis?"

Paper V:

No questions.

2000

Paper IV:

"Tumour formation is a multi-step process.  Discuss the evidence for this
statement."

Paper V:

No questions.