Protein-Nucleic Acid Interactions References

• Trinity term, second year: Dr Wild's Protein-Nucleic Acid Interactions lectures.

• Past Finals questions.

Unspecific Binding To DNA

• Sousa, R, "Structural and mechanistic relationships between nucleic acid polymerases"; Trends In Biochemical Sciences 21(5), 186-90 (1996).

• Brautigam, C and Steitz, T, "Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes"; Current Opinion In Structural Biology 8(1), 54-63 (1998).

• Doublie, S, "Crystal structure of a bacteriophage T7 DNA replication conplex at 2.2 angstrom resolution"; Nature 391, 251-258 (1998).

• Cheetham, G, and Steitz, T, "Insights into transcription: structure and function of single-subunit DNA-dependent RNA polymerases"; Current Opinion In Structural Biology 10(2), 117-123 (2000).

Sequence-Specific DNA-Binding Proteins

Prokaryotic DNA-Binding Proteins

• If anybody knows of any good on-line references, feel free to tell me...

Eukaryotic Transcription Factors

• Bewley, C et al, "Minor groove-binding architectural proteins: structure, function and DNA recognition"; Annual Review Of Biophysics And Biomolecular Structure 27, 105-131 (1998).

• Gourisankar, G, and Van Duyne, G "Pieces of the puzzle: assembling the preinitiation complex of Pol II"; Structure 4(8), 891-895 (1996).

• Song Tan, T, "Eukaryotic transcription factors"; Current Opinion In Structural Biology 8(1) 41-48 (1998).

Homeodomain Proteins

• Burley, S, "The TATA box binding protein"; Current Opinion In Structual Biology 6(1), 69-75 (1996).

• Gajiwala, K, and Burley, S, "Winged helix proteins"; Current Opinion In Structural Biology 10(1), 110-116 (2000).

Zinc Fingers

• Choo, Y, and Klug, A, "Physical basis of a protein-DNA recognition code"; Current Opinion In Structural Biology 7(1), 117-125 (1997).

• Mackay, J, and Crossley, M, "Zinc fingers are sticking together"; Trends In Biochemical Sciences 23(1), 1-4 (1998).

Leucine Zippers

• Chen, L et al, "Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA"; Nature 392, 42-48 (1998).

NF-kB

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RNA and RNA-Binding Proteins

• Conn, G, and Draper, D, "RNA structure"; Current Opinion In Structural Biology 8(3), 278-285 (1998).

• Woodson, S, and Leontis, N, "Structure and dynamics of ribosomal RNA"; Current Opinion In Structural Biology 8(3), 294-300 (1998).

• Cusack, S, "RNA-protein complexes"; Current Opinion In Structural Biology 9(1), 66-73 (1999).

• Handa, N et al, "Structural basis for recognition of the tra mRNA precursor by the sex-lethal protein"; Nature 398, 579-585 (1999).

• Varani, G, and Nagai, K, "RNA recognition by RNP proteins during RNA processing"; Annual Review Of Biophysics And Biomolecular Structure 27, 407-445 (1998).

• Arnez, J, and Moras, D, "Structural and functional considerations of the aminoacylation reaction"; Trends In Biochemical Sciences 22(6), 211-216 (1997).

• Clark, B, and Nyborg, J, "The ternary complex of EF-Tu and its role in protein biosynthesis"; Current Opinion In Structural Biology 7(1), 110-116 (1997).

• Schmitt, E et al, "Crystal structure of methionyl-tRNAfMet transformylase complexed with the initiator formyl-methionyl-tRNAfMet"; EMBO Journal 17, 6819-6826 (1998).

This page was written by Niall Harrison.